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Wednesday, May 16, 2012

SARM LGD-4033 Effects


The effects of LGD-4033 selective androgen receptor modulator on serum total testosterone levels, free testosterone, sex hormone–binding globulin, luteinizing hormone, follicle-stimulating hormone, and prostate-specific antigen.


(A) The effects of LGD-4033 selective androgen receptor modulator on serum total testosterone levels. Change from baseline in serum total testosterone levels are shown. The data are mean ± standard error of the mean (SEM), n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(B) Change in the free testosterone levels from baseline. Change from baseline in serum free testosterone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(C) Change in sex hormone–binding globulin levels from baseline. Change from baseline in serum sex hormone–binding globulin levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(D) Change in luteinizing hormone (U/L) levels from baseline. Change from baseline in serum luteinizing hormone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(E) Change in follicle-stimulating hormone (U/L) levels from baseline. Change from baseline in serum follicle-stimulating hormone levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.

(F) Change in prostate-specific antigen (ng/mL) levels from baseline. Change from baseline in prostate-specific antigen levels is shown. The data are mean ± SEM, n = 33 in the placebo group, 18 in the 0.1-mg dose, 11 in the 0.3-mg group, and 14 in the 1.0-mg group. BL = baseline. The shaded area highlights the 21-day treatment period.


Basaria S, Collins L, Dillon EL, et al. The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. http://biomedgerontology.oxfordjournals.org/content/early/2012/03/28/gerona.gls078.abstract